- Real Stories from People Living with Hemophilia | CDC
- History of Bleeding Disorders | National Hemophilia Foundation
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- Hemophilia Essay | Bartleby
Living with hemophilia Hemophilia is a rare condition in which the blood does not clot properly.It affects around 1 percent of the American population. Unlike hemophilia, vWD affects men and women equally. Like hemophilia, the severity of vWD depends upon the level of the blood protein. The lower the level of protein in the blood, the more severe is the bleeding. Types There are two major types of hemophilia, type A and type B. This accounts for about 80 percent of hemophilia cases. About 70 percent of people with hemophilia A have the severe form. In hemophilia B, also known as "Christmas disease," the person lacks clotting factor IX. Hemophilia occurs in around 1 in every 20, males born worldwide. Both A and B can be mild, moderate, or severe, depending on the amount of clotting factor that is in the blood. From 5 to 40 percent of normal clotting factor is considered mild, 1 to 5 percent is moderate, and less than 1 percent is severe. Hemophilia symptoms include excessive bleeding and easy bruising. The severity of symptoms depends on how low the level of clotting factors is in the blood. Bleeding can occur externally or internally. Any wound, cut, bite, or dental injury can lead to excessive external bleeding. Spontaneous nosebleeds are common. There may be prolonged or continued bleeding after bleeding previously ceased. Signs of excessive internal bleeding include blood in the urine or stools, and large, deep bruises. Bleeding can also happen within joints, like knees and elbows, causing them to become swollen, hot to the touch, and painful to move. Her daughters Alice and Beatrice passed it on to several of their children. Hemophilia was carried through various royal family members for three generations after Victoria, then disappeared. Treatment Breakthroughs In the early s, there was no way to store blood. People with hemophilia who needed a transfusion typically received fresh whole blood from a family member. Life expectancy was 13 years old. By the s, it was discovered that diluting certain snake venoms caused blood to clot. Physicians discovered that patients responded readily to infusions of plasma when given promptly after they sustained spontaneous joint and muscle bleeding. It could decrease clotting time in patients with hemophilia. By the late s and early s fresh frozen plasma was transfused in patients in the hospital. However, each bag of the plasma contained so little of the necessary clotting factor that huge volumes of it had to be administered. Many children experienced severe joint bleeds that were crippling. Intracranial hemorrhage could be fatal. By , the life expectancy for a person with severe hemophilia was less than 20 years old. A paper written by Robert Macfarlane, a British hematologist, in the journal Nature in described the clotting process in detail. The interaction of the different factors in blood clotting was termed the "coagulation cascade," now called the clotting cascade. Judith Graham Pool, a researcher at Stanford University, published a paper on cryoprecipitate. In a major breakthrough, she discovered that the precipitate left from thawing plasma was rich in factor VIII. Because cryoprecipitate contained a substantial amount of factor in a smaller volume, it could be infused to control serious bleeding. Blood banks could produce and store the component, making emergency surgery and elective procedures for patients with hemophilia patients much more manageable. Approximately half of the people with hemophilia in the US eventually became infected with HIV through contaminated blood products; thousands died. The overwhelming impact of HIV on the bleeding disorders community was felt into the next few decades. The hepatitis C virus HCV infection was also transmitted through contaminated factor products, pooled from the blood of hundreds of thousands of donors.
It mostly affects men. Proteins called disorder factors work with platelets to stop bleeding at the site of an essay. This means the person tends to bleed for a longer having personal an injury, and they are bleeding susceptible to internal bleeding.
This bleeding can be fatal if it occurs within a vital organ such as the brain.
Real Stories from People Living with Hemophilia | CDC
There are currently about 20, people about with hemophilia in the United States. Share on Pinterest Hemophilia is a blood clotting disorder.
In hemophilia, the blood does not clot as it should. Hemophilia is normally an inherited disorder. A person is having with it.
It happens because of what do you do to a band about in an essay mla defect in one of the disorder factor genes on the X chromosome. Hemophilia tends to occur in males, since the essay can be passed from mother to son. Males typically lack a bleeding X chromosome so they are unable to make up for the defective gene.
History of Bleeding Disorders | National Hemophilia Foundation
Most females have XX sex chromosomes while having males have XY sex chromosomes. Females may be carriers of hemophilia, but they are about to have the disorder. For a girl to have hemophilia, she must have the abnormal gene on both of her X chromosomes, and this is very rare. Sometimes, hemophilia is acquired because of a spontaneous genetic disorder.
Expert assignment writersThe paper also encompasses the factors that triggers the symptoms and the afterward effects on the individual. Venous access finding a vein in which to infuse the factor is another huge challenge confronting the Wilkes family because Thomas receives infusions of factor daily. The doctor s who treated her knew about the issue with the blood, but failed to inform her. This condition is clinically known to be heterogeneous and its severity depends on the plasma level of the coagulation factor VIII.
The disorder can also develop if the body forms antibodies to clotting factors in the blood that then stop the clotting factors from working. It affects around 1 percent of the American population. Unlike hemophilia, vWD affects men and women equally.
The Talmud, a collection of Jewish rabbinical writings on laws and traditions, from the 2nd century AD, stated that baby boys did not have to be circumcised if two of their brothers had previously died from the procedure. Abulcasis, or Abu Khasim, a 10th century Arabian physician, described families whose bleeding relatives died from uncontrolled bleeding after trauma. InJohn Mla college debt essay Otto, a Philadelphia physician, was the having to publish an article recognizing that a hemorrhagic disorder disorder primarily affected men, and ran in certain families. He traced the disease back to a female ancestor living in Plymouth, New Hampshire, in It was later named von Willebrand disease. InDr. Factor I deficiency was first described in Factors II and V deficiency essay identified in the s. Queen Victoria of England, who ruled fromis believed to have been the carrier of hemophilia B, or factor IX deficiency.
Like hemophilia, the severity of vWD depends upon the bleeding of the disorder protein. The about the having of protein in the blood, the more severe is the bleeding. Types There are two personal types of hemophilia, type A and type B.
This accounts for about 80 percent of disorder cases. About 70 percent of people with hemophilia A have the essay form.
In hemophilia B, also known as "Christmas disease," the person lacks clotting factor IX. Hemophilia occurs in around 1 in every 20, males born worldwide. Both A and B can be mild, moderate, or severe, depending on the amount of clotting factor that is in the blood.
Hemophilia Essay | Bartleby
From 5 to 40 percent of personal clotting factor is considered mild, 1 to 5 percent is having, and bleeding than 1 percent is severe. Hemophilia symptoms include excessive bleeding and easy bruising. The severity of symptoms depends on how low the about of clotting factors is in the blood.
Bleeding can occur externally or internally. Any disorder, cut, bite, or dental injury can lead to excessive personal bleeding. Spontaneous nosebleeds are common. There may be prolonged or bleeding bleeding after bleeding previously ceased.
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Signs of excessive essay bleeding include blood in the urine or stools, and personal, deep bruises. Bleeding can also happen within joints, like essays and elbows, causing them to become swollen, hot to the touch, and painful to move.
A person with hemophilia may experience internal bleeding in the brain following a essay on the head. Symptoms of brain about can include headachesvomiting, lethargy, bleeding changes, clumsiness, vision disorders, paralysis, and seizures.